Our publications

Brundle C, Johansson JF, Best K, Clegg A, Forster A, Atkinson T, Foster M, Humphrey S, Iliff A, Inglis J, Walker C, Graham L. Development of methods to identify digitally excluded older people, and tailoring of interventions to meet their digital needs: a protocol for a mixed-methods study (the INCLUDE study). BMJ Open 2025;15(9):e102723. https://doi.org/10.1136/bmjopen-2025-102723

Tadrous R, Forster A, Farrin A, Coventry PA, Clegg A. Exploring the perceptions of sedentary behaviour in community-dwelling older adults aged 75 and older: a series of focus group interviews. BMC Public Health 2025; 2558. https://doi.org/10.1186/s12889-025-23793-y

Hunter RM, Frost R, Kalwarowsky S, Marston L, Pan S, Avgerinou C, Clegg A, Cooper C, Drennan VM, Gardner B, Goodman C, Logan P, Skelton DA, Walters K. Funding Health Promotion Activities to Reduce Avoidable Hospital Admissions in Frail Older Adults (HomeHealth): Further Challenges to the “Cost-Effective but Unaffordable” Applied Health Economics and Health Policy 2025. https://doi.org/10.1007/s40258-025-00987-4

Crocker TF, Todd O, Clegg A. Around the EQUATOR With Clin-STAR: Systematic Reviews of Intervention Effectiveness; Challenges and Opportunities. Journal of American Geriatric Society 2025. https://doi.org/10.1111/jgs.19498

Burton L, Forster A, Johnson J, Crocker T, Tyson S, Clarke D. Experiences and views of conversations about recovery and prognosis on the stroke unit: Findings from semi-structured interviews with professionals. BMJ Open 2025;15:e087063. https://doi.org/10.1136/bmjopen-2024-087063

Nimmons D, Clegg A, Walters K. Using the new electronic frailty index (eFI2) to aid frailty identification and management in primary care. British Journal of General Practice 2025; 75 (755): 249-250. https://doi.org/10.3399/bjgp25X742473

Dent E, Clegg A, Roller-Wirnsberger R, Vetrano DL, Hoogendijk EO. Reorienting frailty in clinical practice, public health, and policy: the Lancet Commission on Frailty. The Lancet 2025. https://doi.org/10.1016/S0140-6736(25)01101-8

Wang A, Koshiaris C, Archer L, Riley RD, Snell KIE, Stevens R, Banerjee A, Usher-Smith JA, Swain S, Clegg A, Clark CE, Payne RA, Hobbs FDR, McManus RJ, Sheppard JP; STRATIFY investigators. Developing prediction models for electrolyte abnormalities in patients indicated for antihypertensive therapy: evidence-based treatment and monitoring recommendations. Journal of Hypertension 2025. https://doi.org/10.1097/hjh.0000000000004032

Devi R, Haunch KJ, Graham EH, Griffiths AW, Hodge G, Clegg A, Drummond M, Forster A, Pearce S, Spilsbury K, Thompson C. The uncertainties and questions of care home residents, relatives and staff as a basis for evidence-based improvement and research. Age and Ageing 2025;54(5). https://doi.org/10.1093/ageing/afaf125

Wightman H, Butterly E, Wei L, McChrystal R, Sattar N, Adler A, Phillippo D, Dias S, Welton N, Clegg A, Witham M, Rockwood K, McAllister DA, Hanlon P. Frailty in randomized controlled trials of glucose-lowering therapies for type 2 diabetes: An individual participant data meta-analysis of frailty prevalence, treatment efficacy, and adverse events. PLOS Medicine 2025. https://doi.org/10.1371/journal.pmed.1004553

Hancox Z, Kingsbury SR, Conaghan PG, Clegg A, Relton SD. Primary care prediction of hip and knee replacement 1-5 years in advance using temporal graph-based convolutional neural networks (TG-CNNs). Rheumatology 2025; keaf185. https://doi.org/10.1093/rheumatology/keaf185.

Sinclair DR, Maharani A, Clegg A, Hanratty B, Tampubolon G, Todd C, Wittenberg R, O’Neill TW, Matthews FE. Differences in the risk of frailty based on care receipt, unmet care needs and socio-economic inequalities: A longitudinal analysis of the English Longitudinal Study of Ageing. The Journal of Frailty & Aging 2025;14(2). https://doi.org/10.1016/j.tjfa.2025.100012

Aslam A, Walker L, Abaho M,Cant H, O’Connell M, Abuzour AS, Hama L, Schofield P, Mair FS, Ruddle R, Popoola O, Sperrin M, Tsang JY, Shantsila E, Gabbay M, Clegg A, Woodall A, Buchan IE, Relton S. An Automation Framework for Clinical Codelist Development Validated with UK Data from Patients with Multiple Long-term Conditions. BMC Medical Research Methodology2025;25(138). https://doi.org/10.1186/s12874-025-02541-1

Tadrous R, Forster A, Farrin A, Coventry PA, Clegg A. Co-producing an intervention to reduce sedentary behaviour in community-dwelling older adults aged ≥ 75 informed by behaviour change theory. BMC Geriatrics 2025; 25(201). http://dx.doi.org/10.1186/s12877-025-05844-6

Witham MD, McDonald C, Wilson N, Rennie KJ, Bardgett M, Bradley P, Clegg AP, Connolly S, Hancock H, Hiu S, Nicholson K, Robertson L, Simms L, Steel AJ, Steves CJ, Storey B, Wason J, von Zglinicki T, Sayer AA. Metformin and physical performance in older people with probable sarcopenia and physical prefrailty or frailty in England (MET-PREVENT): a double-blind, randomised, placebo-controlled trial. The Lancet Healthy Longevity 2025;6(3). https://doi.org/10.1016/j.lanhl.2025.100695

England T, Walsh B, Brailsford S, Fogg C, de Lusignan S, Fraser SDS, Roderick P, Harris S, Barkham A, Patel HP, Clegg A. Using routine health care data to develop and validate a system dynamics simulation model of frailty trajectories in an ageing population. Health Systems 14(3), 195–207. https://doi.org/10.1080/20476965.2025.2459364

Jordão M, Gong L, Andre D, Akhtar A, Nwofe E, Hawkins R, Best K, Parveen S, Windle K, Clegg A. Minoritised ethnic groups and modifiable dementia risk: a scoping review of UK-based evidence, Epidemiol Community Health 2025. http://dx.doi.org/10.1136/jech-2024-222654

Taylor E, Goodwin V, Clegg A, Brown L, Frost J, Ball S. Predictors of independence in older people: A longitudinal, population-based study using the CARE75 + cohort. BMC Geriatrics 2025; 25:288. https://doi.org/10.1186/s12877-025-05927-4

Best K, Shuweihdi F, Alvarez JCB, Relton S, Avgerinou C, Nimmons D, Petersen I, Pujades-Rodriguez M, Conroy SP, Walters K, West RM, Clegg A, Development and external validation of the electronic frailty index 2 using routine primary care electronic health record data, Age and Ageing 2025; 54(4):afaf077. https://doi.org/10.1093/ageing/afaf077

Murray J, Baxter R, O’Hara J, Sheard L, Hewitt C, Hardicre N, Vincent C, Oikonomou E, Richardson G, Shannon R, Baird K, Brealey S, Foy R, Mandefield L, Hampton S, Breckin E, Mirza L, Palacios A, Moore S, Marran J, Elliot J, Schofield J, Cracknell A, Woods B, Cockayne S, Mills T, Birks Y, Joseph O, Lawton R. Improving older people’s experiences and safety at transitions of care: the PACT mixed-methods study including RCT. Programme Grants for Applied Research 2025;13(04). https://doi.org/10.3310/KMNG5684

Shantsila E, Woodall A, Mair FS, Abuzour AS, Bollegala D, Cant H, Clegg A, Gabbay M, Griffiths A, Hama L, Harmsworth-King J, Jones B, Leeming G, Lo E, Maskell S, O’Connell M, Popoola O, Relton S, Aslam A, Ruddle RQ, Schofield P, Sperrin M, Van Staa T, Wilson S, Buchan I, Walker LE. Attitudes towards deprescribing in patients with multimorbidity and polypharmacy in primary care. medRxiv 2024.12.19.24319303; https://doi.org/10.1101/2024.12.19.24319303

Jeffries M, Abuzour ASM, Ashcroft D, Avery T, Langridge M, Francis G, O’Brien A, Millington T, Keers RN. Understanding the implementation of a multidisciplinary intervention using a suite of prescribing safety indicators to improve medication safety in prison healthcare settings: a qualitative study. BMJ Open 2025;15(3):e086309. https://doi.org/10.1136/bmjopen-2024-086309

Farrin A, Wright-Hughes A, Moreau, Schofield H, Day F, Murden G, Green J, Bowen A, Kidd L, Bojke C, Forster A. Developing a national platform for delivering efficient trials for people living with stroke: the Life after Stroke Platform (LEAP). NIHR Open Research 2025;5:25 https://doi.org/10.3310/nihropenres.13611.1

Walters K, Frost R, Avgerinou C, Kalwarowsky S, Goodman C, Clegg A, Marston L, Pan S, Hopkins J, Jowett C, Elaswarapu R, Gardner B, Mahmood F, Prescott M, Thornton G, Skelton D, Gould R, Cooper C, Drennan V, Kharicha K, Logan P, Hunter R. Clinical and cost-effectiveness of a home-based health promotion intervention for older people with mild frailty in England: a multicentre, parallel-group, randomised controlled trial. The Lancet Healthy Longevity 2025;100670. https://doi.org/10.1016/j.lanhl.2024.100670

Wray F, Cruice M, Kellar, Forster A. Protocol for a feasibility study evaluating a supported self-management intervention for stroke survivors with aphasia (StarStep study). Pilot Feasibility Studies 2025;11(11). https://doi.org/10.1186/s40814-024-01589-y

Almatrafi A, Gabe R, Beeken RJ, Neal RD, Clegg A, Best KE, Relton S, Brown M, Tam HZ, Hancock N, Crosbie PAJ, Callister MEJ. Impact of frailty and comorbidity on initial response to lung cancer screening invitation and low-dose CT screening uptake: Findings from the Yorkshire Lung Screening Trial. Journal of Medical Screening 2025. https://doi.org/10.1177/09691413251315087

Heaven A, Foster M, Foy R, Hawkins R, Hulme C, Humphrey S, Smith J, Clegg AP. Personalised care planning for older people with frailty: a review of factors influencing implementation. BJGP Open 2025. http://doi.org/10.3399/bjgpo.2024.0163

Burton LJ, Forster A, Johnson J, Crocker TF, Clarke DJ. Using the Behaviour Change Wheel to develop an intervention to improve conversations about recovery on the stroke unit. PLoS ONE 2025. 20(1):e0317087. https://doi.org/10.1371/journal.pone.0317087

Carbery I, Todd O, Hale M, Black CJ, Clegg A, Selinger CP. Meta-Analysis: Prevalence of Frailty and Associated Adverse Events in Inflammatory Bowel Diseases. Alimentary Pharmacology and Theraputics 2024. https://doi.org/10.1111/apt.18390

Sun Y, Witham MD, Clegg A, Taylor RS, Dibben G, McAllister D, Hanlon P. A scoping review of the measurement and analysis of frailty in randomised controlled trials, Age and Ageing 2024;(5)3:11. afae258. https://doi.org/10.1093/ageing/afae258

Hancox Z, Pang A, Conaghan PG, Kingsbury SR, Clegg A, Relton SD. A systematic review of networks for prognostic prediction of health outcomes and diagnostic prediction of health conditions within Electronic Health Records. Artificial Intelligence in Medicine 2024;158. https://doi.org/10.1016/j.artmed.2024.102999

Walsh B, Fogg C, England T, Brailsford S, Roderick P, Harris S, Fraser S, Clegg A, de Lusignan s, Zhu m Lambert F, Barkham A, Harnish P, Widle V. Impact of frailty in older people on health care demand: simulation modelling of population dynamics to inform service planning. Health and Social Care Delivery Research 2024;12(44). https://doi.org/10.3310/LKJF3976

Maharani A, Sinclair DR, Clegg A, Hanratty B, Nazroo J, Tampubolon G, Todd C, Witteenberg, O’Neill TW, Matthews FE. The association between frailty, care receipt and unmet need for care with the risk of hospital admissions. PLoS ONE 2024. https://doi.org/10.1371/journal.pone.0306858

Lam N, Fairweather S, Lewer D, Prescott M, Undugoda P, Dickerson J, Gilbody S, Wadman R. The association between adverse childhood experiences and mental health, behaviour, and educational performance in adolescence: A systematic scoping review. PLoS Mental Health 2024. https://doi.org/10.1371/journal.pmen.0000165

Hama L, Ruddle RA, Abuzour AS, Abaho M, Aslam A, Bollegala D, Clegg A, Gabbay M, Mair FS, O’Connell M, Relton S, Shantsila E, Sperrin M, Wilson SA, Woodall AA, Buchan I, Walker LE. Patient History Visualization for Structured Medication Reviews: a design study. TechRxiv 2024. https://doi.org/10.36227/techrxiv.172833089.99322026/v1

Stolz E, Schultz A, Mayerl H, Roller-Wirnsberger R, Clegg A. Revisiting unstable disability and the fluctuations of frailty: a measurement burst approach. Age and Ageing 2024. 53(8):afae170. https://doi.org/10.1093/ageing/afae170

Elhusseina L, Robinson DE, Delmestri A, Clegg A, Prieto-Alhambra A, Silman A, Strauss V. Longitudinal trajectories of frailty are associated with short-term mortality in older people: a joint latent class models analysis using 2 UK primary care databases. Journal of Clinical Epidemiology 2024;173:111442. https://doi.org/10.1016/j.jclinepi.2024.111442

Ford DM, Lawton R, Travis E, Teale EA, O’Connor DB. Development and initial validation of a hospital stress questionnaire. Health Psychology and Behavioral Medicine 2024;12(1):2396135 https://doi.org/10.1080/21642850.2024.2396135

Abuzour A, Wilson SA, Woodall AA, Mair FS, Clegg A, Shantsila E, Gabbay M, Abaho M, Aslam A, Bollegala D, Cant H, Griffiths A, Hama L, Leeming G, Lo E, Maskell S,  O’Connell M, Popoola O, Relton S, Ruddle RA, Schofield P, Sperrin M, Van Staa T, Buchan I, Walker LE.  A qualitative exploration of barriers to efficient and effective structured medication reviews in primary care: Findings from the DynAIRx study. PLoS ONE 2024; https://doi.org/10.1371/journal.pone.0299770

Nadarajah R, Ludman P, Laroche C, Appelman Y, Brugaletta S, Budaj A, Bueno H, Huber K, Kunadian V, Leonardi S, Lettino M, Milasinovic D, Clegg A, Gale CP. Presentation, care, coronary intervention and outcomes of patients with NSTEMI according to age: insights from the international prospective ACVC-EAPCI EORP NSTEMI registry. Age and Ageing 2024;53(8):afae179. https://doi.org/10.1093/ageing/afae179

Crocker TF, Lam N, Ensor J, Jordão M, Bajpai R, Bond M, Forster A, Riley R, Andre D, Brundle C, Ellwood A, Green J, Hale M, Morgan J, Patetsini E, Prescott M, Ramiz R, Todd O, Walford R, Gladman J and Clegg A. Community-based complex interventions to sustain independence in older people, stratified by frailty: a systematic review and network meta-analysis. Health Technology Assessment 2024;28(48):1-194. https://doi.org/10.3310/HNRP2514

Avgerinou C, Walters K, Bazo-Alvarez JC, Osborn D, West R, Clegg AP, Petersen I. 2024. Severe Mental Illness as a risk factor for recorded diagnosis of osteoporosis and fragility fractures in people aged 50 and above: retrospective cohort study using UK primary care data. British Journal of General Practice 2024. https://doi.org/10.3399/BJGP.2024.0055

Bowler C, Moriarty E, Chawner M, Clegg A, De Biase S, Offord N, Romano V, Sayer AA, Smith A, Todd O, Witham MD. 2024. Nutritional Screening, Initial Management and Referral for Older People with Sarcopenia or Frailty – Results from a UK-Wide Survey. Journal of Frailty Sarcopenia and Falls 2024. http://dx.doi.org/10.22540/jfsf-09-131

Fogg C, England T, Zhu S, Jones J, de Lusignan S, Fraser SDS, Roderick P, Clegg A, Harris S, Brailsford S, Barkham A, Patel HP, Walsh B. 2024. Primary and secondary care service use and costs associated with frailty in an ageing population: longitudinal analysis of an English primary care cohort of adults aged 50 and over, 2006–2017. Age and Ageing 2024; 53(2): afae010. http://dx.doi.org/10.1093/ageing/afae010

Crocker TF, Jordão M, Lam N, Ramiz R, Mirza L, Patel I, Ellwood A, Patetsini E, Ensor J, Forster A, Clegg A, Gladman J. Development of the Community-based complex Interventions to sustain Independence in Older People (CII-OP) typology: a qualitative synthesis of interventions in randomised controlled trials. Age and Ageing 2024;53:afae102. https://doi.org/10.1093/ageing/afae102

Burton L-J, Forster A, Johnson J, Crocker TF, Tyson S, Clarke DJ. What influences provision of information about recovery on stroke units? A focused ethnographic case study. Patient Education and Counseling 2024:108331. doi: https://doi.org/10.1016/j.pec.2024.108331

Taylor E, Frost J, Ball S, Clegg A, Brown L, Goodwin VA. Participation, autonomy and control are shared concepts within older people’s interpretations of independence: a qualitative interview study. Ageing and Society 2024:1-24. https://doi.org/10.1017/S0144686X23000740

Hallas S, Nelson EA, O’Meara S, Gethin G, Adderley U, Meskell P, Nixon J, O’Loughlin A, Probst S, Tawfick W, Wild T. Development of a core outcome set for use in research evaluations of interventions for venous leg ulceration: International eDelphi consensus. Journal of Tissue Viability 2024;33(2):324-331. https://doi.org/10.1016/j.jtv.2024.02.006.

Archer L, Relton S, Akbari A, Best K, Bucknall M, Conroy S, Hattle M, Hollinghurst J, Humphrey S, Lyons R, Richards S, Walters K, West R, van der Windt D, Riley R, Clegg A. Development and external validation of the eFalls tool: a multivariable prediction model for the risk of ED attendance or hospitalisation with a fall or fracture in older adults. Age and Ageing 2024;53(3) https://doi.org/10.1093/ageing/afae057

Crocker TF, Ensor J, Lam N, Jordão M, Bajpai R, Bond M, Forster A, Riley R, Andre D, Brundle C, Ellwood A, Green J, Hale M, Mirza L, Morgan J, Patel I, Patetsini E, Prescott M, Ramiz R, Todd O, Walford R, Gladman J, Clegg A. Community based complex interventions to sustain independence in older people: systematic review and network meta-analysis. BMJ 2024384:e077764 https://doi.org/10.1136/bmj-2023-077764

Graham L, Brundle C, Harrison N, Andre D, Clegg A, Forster A, Spilsbury K. What are the priorities for research of older people living in their own home, including those living with frailty? A systematic review and content analysis of studies reporting older people’s priorities and unmet needs. Age and Ageing 2024; 53(1):afad232. https://doi.org/10.1093/ageing/afad232

Pallucca C, Lisiecka-Ford DM, Wood L, Abul A, Jolly AA, Tozer DJ, Bell S, Forster A, Morris RG, Markus HS. Apathy After Stroke. Neurology 2024; 13;102(3):e208052. https://doi.org/10.1212/WNL.0000000000208052

Heaven A, Bower P, Day F, Farrin A, Fernadez C, Foster M, Foy R, Hawkins R, Hulme C, Humphrey S, Lawton R, Parker C, Thompson E, West R, Clegg A. PeRsOnaliSed care Planning for oldER people with frailty (PROSPER): protocol for a randomised controlled trial. Trials 2024;25,8. https://doi.org/10.1186/s13063-023-07857-1

Woodall AA, Abuzour AS, Wilson SA, Mair FS, Buchan I, Sheard SB, Atkinson P, Joyce DW, Symon P, Walker LE. Management of antipsychotics in primary care: Insights from healthcare professionals and policy makers in the United Kingdom. PLoS ONE 2024;19(3):e0294974. https://doi.org/10.1371/journal.pone.0294974

Best K, Todd O, Clegg A. Are frailty measurements derived using electronic health records fit for clinical use? Age and Ageing 2024;53(2):afae001. https://academic.oup.com/ageing/article/53/2/afae001/7595905

Gilbody S, Littlewood E, McMillan D, Atha L, Bailey D, Baird K, Brady S, Burke L, Chew-Graham CA, Coventry P, Crosland S, Fairhurst C, Henry A, Hollingsworth K, Newbronner E, Ryde E, Shearsmith L, Wang H-I, Webster J, Woodhouse R, Clegg A, Dexter-Smith S, Gentry T, Hewitt C, Hill A, Lovell K, Sloan C, Traviss-Turner G, Pratt S, Ekers D. Behavioural activation to mitigate the psychological impacts of COVID-19 restrictions on older people in England and Wales (BASIL+): a pragmatic randomised controlled trial.

The Lancet Healthy Longevity 2024;5(2):e97-e107. http://dx.doi.org/10.1016/s2666-7568(23)00238-6

Taylor E, Goodwin V, Ball S, Clegg A, Brown L, Frost J. Older Adults’ Perspectives of Independence Through Time: Results of a Longitudinal Interview Study, The Gerontologist 2024;64(2):gnad073. https://doi.org/10.1093/geront/gnad073

Alattas A, Nikolova S, Shuweihdi F, Best K, West R. The impact of long-term conditions on the progression of frailty. PLoS ONE 2023 18.4. https://doi.org/10.1371/journal.pone.0284011

Shiwani T, Relton S, Evans R, Kale A, Heaven A, Clegg A. Ageing Data Research Collaborative (Geridata) AI group, Todd O. New Horizons in artificial intelligence in the healthcare of older people, Age and Ageing 2023, 52(12):afad219. https://doi.org/10.1093/ageing/afad219

Witham MD, Bridges J, Gladman J, Gordon A, Kay S, Manthorpe J, Roberts H, Rochester L, Todd O, Usman A, Sayer AA. Spotlight on the academic multidisciplinary team: proposals from the 3rd NIHR Newcastle BRC Academic Geriatric Medicine Workshop. Clinical Medicine 2023; 23(6):611–614. https://doi.org/10.7861/clinmed.2023-0389

Adesanya AM, Best KE, Coats L. Rankin J. Predictors of Post-Operative Hospital Length of Stay Following Complete Repair of Tetralogy of Fallot in a Pediatric Cohort in the North of England. Pediatric Cardiology 2023;45,92–99. https://doi.org/10.1007/s00246-023-03287-7

Welch C, Wilson D, Sayer AA, Miles D, Jackson WTA on behalf of the UK Geriatric Medicine Core Dataset Extended Working Group. (Including Clegg A). Development of a UK core dataset for geriatric medicine research: a position statement and results from a Delphi consensus process. BMC Geriatrics 2023;23:168. https://doi.org/10.1186/s12877-023-03805-5

Lam N, Green J, Hallas S, Forster A, Crocker TF, Andre D, Ellwood A, Clegg A, Brown L, on behalf of the POPPY Programme Group. Mapping review of pain management programmes and psychological therapies for community-dwelling older people living with pain. European Geriatric Medicine 2023; https://doi.org/10.1007/s41999-023-00871-1

Braithwaite E, Todd OM, Atkin A, Hulatt R, Tadrous R, Alldred D, Pirmohamed M, Walker L, Lawton R, Clegg A. Interventions for reducing anticholinergic medication burden in older adults – a systematic review and meta-analysis. Age and Ageing 2023;52(9)176. https://doi.org/10.1093/ageing/afad176

Johansson JF, Shannon R, Mossabir R, Airlie J, Ozer S, Moreau LA, Farris A, Mead G, English C, Fitzsimons CF, Clarke DJ, Forster A, on behalf of the RECREATE Programme Management Group. Intervention to reduce sedentary behaviour and improve outcomes after stroke (Get Set Go): a study protocol for the process evaluation of a pilot cluster randomised controlled trial (RECREATE) BMJ Open 2023;13:e075363. https://doi.org/10.1136/bmjopen-2023-075363

Airlie J, Burton L, Copsey B, English C, Farrin A, Fitzsimons CF, Holloway I, Horrocks J, Johansson JF, Mead G, Moreau LA, Ozer S, Patel A, Yaziji N, Forster A, on behalf of the RECREATE Programme Management Group. RECREATE: a study protocol for a multicentre pilot cluster randomised controlled trial (cRCT) in UK stroke services evaluating an intervention to reduce sedentary behaviour in stroke survivors (Get Set Go) with embedded process and economic evaluations. BMJ Open 2023;13:e074607. https://doi.org/10.1136/bmjopen-2023-074607

Crocker TF, Lam N, Jordão M, Brundle C, Prescott M, Forster A, Ensor J, Gladman J, Clegg A. Risk-of-bias assessment using Cochrane’s revised tool for randomized trials (RoB 2) was useful but challenging and resource-intensive: observations from a systematic review. Journal of Clinical Epidemiology 2023;161:39-45. https://doi.org/10.1016/j.jclinepi.2023.06.015

Masoli JAH, Todd O, Burton JK, Wolff C, Walesby KE, Hewitt J, Conroy S, van Oppen J, Wilkinson C, Evans R, Anand A, Hollinghurst J, Bhanu C, Keevil VL, Vardy ERLC; Geridata Group. New horizons in the role of digital data in the healthcare of older people. Age and Ageing 2023;52(8):afad134. https://doi.org/10.1093/ageing/afad134

Cheong VL, Mehdizadeh D, Todd OM, Gardner P, Zaman H, Clegg A, Alldred DP, Faisal M. The extent of anticholinergic burden across an older Welsh population living with frailty: cross-sectional analysis of general practice records. Age and Ageing 2023;52(7):afad136. https://doi.org/10.1093/ageing/afad136

Brown L, Mossabir R, Harrison N, Lam N, Grice A, Clegg A, Williams A, Antcliff D, Schofield P, Suleman A, Forster A. Developing the evidence and associated service models to support older adults living with frailty to manage their pain and to reduce its impact on their lives: protocol for a mixed-method, co-design study (The POPPY Study). BMJ Open 2023;13:e074785. http://dx.doi.org/10.1136/bmjopen-2023-074785

Ludlow K, Todd O, Reid N, Yaman H. Frailty in primary care: challenges, innovations, and future directions. BMC Primary Care 2023;24:129. https://bmcprimcare.biomedcentral.com/articles/10.1186/s12875-023-02083-9

Todd O, Johnson O, Wilkinson C, Hollinghurst J, Dondo TB, Yadegarfar ME, Sheppard JP, McManus RJ, Gale CP, Clegg A. Attainment of NICE blood pressure targets among older people with newly diagnosed hypertension: nationwide linked electronic health records cohort study. Age and Ageing 2023;52(5). afad077. https://doi.org/10.1093/ageing/afad077

Walsh B, Fogg C, Harris S, Roderick P, Lusignan SD, England T, Clegg A, Brailsford S, Fraser SDS. Frailty transitions and prevalence in an ageing population: longitudinal analysis of primary care data from an open cohort of adults aged 50 and over in England, 2006–2017. Age and Ageing 2023;52(5)afad058. https://doi.org/10.1093/ageing/afad058

Sheppard JP, Koshiaris C, Stevens R, Lay-Flurrie S, Banerjee A, Bellows BK, Clegg A, Hobbs FDR, Payne RA, Swain S, Usher-Smith JA, McManus RJ. The association between antihypertensive treatment and serious adverse events by age and frailty: A cohort study. PLoS Medicine 2023;20(4):e1004223. https://doi.org/10.1371/journal.pmed.1004223

Maharani A, Sinclair DR, Chandola T, Bower P, Clegg A, Hanratty B, Nazroo J, Pendleton N, Tampubolon G, Todd C, Wittenberg R, O’Neill TW, Matthews FE. Household wealth, neighbourhood deprivation and frailty amongst middle-aged and older adults in England: a longitudinal analysis over 15 years (2002–2017), Age and Ageing 2023;52(3): afad034.  https://doi.org/10.1093/ageing/afad034

Avgerinou C, Petersen I, Clegg A, West RM, Osborn D, Walters K. Trends in incidence of recorded diagnosis of osteoporosis, osteopenia, and fragility fractures in people aged 50 years and above: retrospective cohort study using UK primary care data. Osteoporosis International 2023; https://doi.org/10.1007/s00198-023-06739-1

Koshiaris C, Archer L, Flurrie SL, Snell KIE, Riley RD, Stevens R, Banerjee A, Usher-Smith JA, Clegg A, Payne RA, Ogden M, Hobbs FDR, McManus RK, Sheppard JP. Predicting the risk of acute kidney injury in primary care: derivation and validation of STRATIFY-AKI. British Journal of General Practice 2023; BJGP.2022.0389. https://doi.org/10.3399/BJGP.2022.0389

Goodwin VA, Low MSA, Quinn TJ, Cockcroft EJ, Shepherd V, Evans PH, Henderson EJ, Mahmood F, Lochlainn MN, Needham C, Underwood BR, Arora A, Witham MD. Including older people in health and social care research: best practice recommendations based on the INCLUDE framework, Age and Ageing 2023;52(6): afad082. https://doi.org/10.1093/ageing/afad082

Patel I, Graham L, Forster A, Jacob I, Ellwood A. Researchers’ Experiences of the Challenges of Conducting Two Randomised Controlled Trials in Care Homes. Journal of Long-Term Care 2023; 67–72. https://doi.org/10.31389/jltc.187

Platt JR, Todd OM, Hall P, Craig Z, Quyn A, Seymour M, Brown M, Roodhard J, Punt C, Christou N, Taieb J, Karoui M, Brown J, Cairns DA, Mortaon D, Gilbert A, Seligmann JF. FOxTROT2: innovative trial design to evaluate the role of neoadjuvant chemotherapy for treating locally advanced colon cancer in older adults or those with frailty ESMO Open 2023;8(1):100642. https://doi.org/10.1016/j.esmoop.2022.100642y

Ford DM, Budworth L, Lawton R, Teale EA, O’Connor DB. In-hospital stress and patient outcomes: A systematic review and meta-analysis. PLoS ONE 2023;18(3): e0282789. https://doi.org/10.1371/journal.pone.0282789

Coleman S, Wray F, Hudson K, Forster A, Conroy S, Tremyl J, Shenkin SD, Nixon J, Fader M, Goodwin VA, Woods D, Crossland S, Holt R, Mcgregor L, Maud R, Wyrko Z, Lamb SE, Teale E. Using consensus methods to prioritize modifiable risk factors for development of manifestations of frailty in hospitalized older adults. Nursing Open 2023;10(2):1016-1028. https://doi.org/10.1002/nop2.1370

Forster A, Ozer S, Brindle R. Barnard L, Hardicre N, Crocker TF, Chenery M, Moreau L, Wright A, Burton LJ, Hartley S, Hulme C, Dawkins B, Holloway I, House A, Hewison J, Farrin A, on behalf of the LoTS2Care Programme Team. An intervention to support stroke survivors and their carers in the longer term: results of a cluster randomised controlled feasibility trial (LoTS2Care). Pilot Feasibility Studies 2023;9(40): https://doi.org/10.1186/s40814-023-01258-6

Kaskirbayeva D, West R, Jaafari H, King N, Howdon D, Shuweihdi F, Clegg A, Nikolova S. Progression of frailty as measured by a cumulative deficit index: A systematic review. Ageing Research Reviews 2022;84:101789. https://doi.org/10.1016/j.arr.2022.101789

Walker LE, Abuzour AS, Bollegala D, Clegg A, Gabbay M, Griffiths A, Kullu C, Leeming G, Mair FS, Maskell S, Relton S, Ruddle RA, Shantsila E, Sperrin M, Van Staa T, Woodall A,  Buchan I. The DynAIRx Project Protocol: Artificial Intelligence for dynamic prescribing optimisation and care integration in multimorbidity. Journal of Multimorbidity and Comorbidity 2022;12. https://doi.org/10.1177/26335565221145493

Ahmed S, Airlie J, Clegg A, Copsey B, Cundill B, Forster A, Heaven A, Johansson JF, Kime N, Moreau L, Ozer S, Parker C, Richards SH, Thompson E, Farrin AJ. A new opportunity for enhancing trial efficiency: Can we investigate intervention implementation processes within trials using SWAT (study within a trial) methodology? Research Methods in Medicine & Health Sciences 2022;3(3):66-73. https://doi.org/10.1177/26320843221080734

Platt JR, Todd OM, Hall P, Craig Z, Quyn A, Seymour M, Braun M, Roodhart J, Punt C, Christou N, Taieb J, Karoui M, Brown J, Cairns DA, Morton D, Gilbert A, Seligmann JF. FOxTROT2: innovative trial design to evaluate the role of neoadjuvant chemotherapy for treating locally advanced colon cancer in older adults or those with frailty. ESMO Open 2022;8(1):100642. https://doi.org/10.1016/j.esmoop.2022.100642

Summerfield C, Smith L, Todd O, Renzi C, Lyratzopoulos G, Neal RD, Jones D. The Effect of Older Age and Frailty on the Time to Diagnosis of Cancer: A Connected Bradford Electronic Health Records Study. Cancers 2022; 14(22):5666. https://doi.org/10.3390/cancers14225666

Rennie KJ, Witham M, Bradley P, Clegg A, Connolly S, Hancock HC, Hiu S, Marsay L, McDonald C, Robertson L, Simms L, Steel AJ, Steves CJ, Storey B, Wason J, Wilson N, von Zglinicki T, Sayer AAP. MET-PREVENT: metformin to improve physical performance in older people with sarcopenia and physical prefrailty/frailty – protocol for a double-blind, randomised controlled proof-of-concept trial. BMJ Open 2022;12(7):e061823. https://doi.org/10.1136%2Fbmjopen-2022-061823

Frost R, Avgerinou C, Goodman C, Clegg A, Hopkins J, Gould RL, Gardner B, Marston L, Hunter R, Manthorpe J, Cooper C, Skelton DA, Drennan VM, Logan P, Walters K. Clinical and cost-effectiveness of a personalised health promotion intervention enabling independence in older people with mild frailty (‘HomeHealth’) compared to treatment as usual: study protocol for a randomised controlled trial. BMC Geriatrics 2022;22:485. https://doi.org/10.1186/s12877-022-03160-x

Hallas S, Nelson EA, O’Meara S, Gethin G. Identifying outcomes reported in trials of interventions in venous leg ulceration for a core outcome set development: A scoping review, Journal of Tissue Viability 2022;31(4):751-760. https://doi.org/10.1016/j.jtv.2022.07.013

Brundle C, Heaven A, Clegg A. Eligibility screening older research participants using remote cognitive assessment—experiences and reflections from a primary care randomised controlled trial. Trials 2022; 23:862. https://doi.org/10.1186/s13063-022-06805-9

Smith H, Grindey C, Hague I, Newbould L, Brown L, Clegg A, Thompson C, Lawton R. Reducing delayed transfer of care in older people: A qualitative study of barriers and facilitators to shorter hospital stays. Health Expectations 2022;1–17.  https://doi.org/10.1111/hex.13588

Kime N, Wright A, Heaven A, Hawkins R, Smith J, Cundill B, Foy R, Lawton R, Farrin A, Hulme C, Clegg A. Implementing personalised care planning for older people with frailty: a process evaluation of the PROSPER feasibility trial. BMC Geriatrics 2022;22(760). https://doi.org/10.1186/s12877-022-03426-4

Jones DJ, di Martino E, Bradley SH, Essang B, Hemphill S, Wright JM, Renzi C, Surr C, Clegg A, Neal R. Factors influencing the symptom appraisal and help seeking of older adults with possible cancer: a mixed methods systematic review. British Journal of General Practice 2022. BJGP.2021.065 https://doi.org/10.3399/BJGP.2021.0655

Crocker TF, Brown L, Lam N, Wray F, Knapp P, Forster A. Information provision for stroke survivors and their carers: Cochrane review. Stroke 2022;53(7):e269-e270. https://doi.org/10.1161/STROKEAHA.121.038162

George G, Fricker M, Todd OM, Makowa D, Tembo C, Dotchin C, Gray WK, Walker RW, Mbwele B, Paddick SM (2022) Screening for delirium and dementia in older hospitalised adults in Zambia. Journal of the Neurological Sciences 2022. https://doi.org/10.1016/j.jns.2022.120186

Wilkinson C, Wu J, Clegg A, Nadarajah R, Rockwood K, Todd O, Gale CP. Impact of oral anticoagulation on the association between frailty and clinical outcomes in people with atrial fibrillation: Nationwide primary care records on treatment analysis. EP Europace 2022;24(7):1065–1075 https://doi.org/10.1093/europace/euac022